Sermorelin Canada: What Sermorelin Peptide Is, CAS 86168-78-7, and vs Tesamorelin and Ipamorelin (Not Stocked)

Sermorelin draws about 2,400 Canadian searches a month, with 1,000 more for "sermorelin peptide" and 320 for "sermorelin canada" (Semrush CA database, October 2026). Hermetica Research Labs does not stock sermorelin. There is no sermorelin product page, price, lot or certificate of analysis on this site, and nothing here is an offer to sell it. This page sets out what identifies sermorelin on paper, for laboratories that hold it from another supplier or need to keep it distinct from tesamorelin, ipamorelin and CJC-1295 in a compound registry. It is limited to structure and documentation and does not discuss any use in humans or animals.

Key takeaways

What is sermorelin?

Sermorelin is the synthetic amide of the first 29 residues of growth hormone-releasing hormone, GHRH(1-29)-NH2, reviewed under that name by Prakash and Goa (1999). It carries no N-terminal modification and no substituted residues, which makes it the reference point against which modified GHRH analogues (tesamorelin, CJC-1295) are usually described. On a certificate, "what is sermorelin" is answered by the 29-residue sequence, the C-terminal amide and an intact mass near 3357.9 Da (PubChem CID 16132413).

"Sermorelin peptide": what the listing phrase means

"Sermorelin peptide" (about 1,000 Canadian searches a month) and "sermorelin peptide canada" are supplier listing phrases, not a different compound. Whatever the listing calls it, the record should show CAS 86168-78-7, the fill mass, the salt form if stated, and a lot number that matches an independent certificate. Oral "tablet" or "pen" listings describe finished formats, not the reagent, and sit outside a laboratory identity record.

Identity fields

Sermorelin is often supplied as an acetate salt. The salt changes the formula weight on the label but not the peptide sequence, so note which form the certificate describes.

The sequence, residue by residue

Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2

Every residue is one of the twenty coded amino acids and none is modified, which makes sermorelin the simplest member of the GHRH-derived group to document. There is one methionine (position 27), three arginines and two lysines.

Three identity checks specific to sermorelin

1. Amide or free acid. The reference compound ends in an amide. The free-acid version of the same chain is about 1 Da heavier (3358.9 Da instead of 3357.9 Da). High-resolution mass data can resolve that difference; a nominal-mass result cannot. If the certificate does not state the C-terminal form, ask the supplier.

2. Full-length vs truncated. Because sermorelin is itself a fragment, a supplier error in the other direction, such as the 44-residue parent sequence or a shorter fragment, shows up as a large mass difference. A mass near 5040 Da would indicate full GHRH(1–44) amide, not sermorelin.

3. Oxidised methionine. Methionine 27 can oxidise during handling, adding 16 Da. A certificate that reports this variant separately from the main peak is more useful than a single purity percentage.

Sermorelin beside related GHRH peptides

The first two rows differ by only about 10 Da in mass, so mass alone is weak evidence for telling them apart. Sequence confirmation, or at least a supplier statement of the full sequence, is the stronger record. More detail is in the Tesamorelin notes and the CJC-1295 and Ipamorelin notes.

What to file when sermorelin material is received

• The name, fill mass and lot exactly as printed on the vial.
• CAS 86168-78-7, or the supplier's explanation for a different CAS (a salt form, for example).
• The certificate issuer, its test or accession number, and confirmation on the issuer's own system.
• The reported mass and the stated C-terminal form.
• The supplier's stated storage condition.
• A note that the material is a laboratory reagent for in-vitro work.

Salt form and fill mass

A 29-residue peptide with three arginines and two lysines carries several positive charges, so it is usually isolated as a salt. Acetate is common. The counter-ions add to the powder mass, which means a vial labelled with a given number of milligrams contains less peptide than that figure. Net peptide content, where a certificate reports it, gives the peptide share of the powder; HPLC purity describes something different, namely the proportion of peptide-related material that is the intended sequence. Record both if both are given, and note which salt the supplier names.

Questions to put to a supplier

• Is the C-terminus an amide, as in the reference compound?
• Which salt form is supplied, and does the CAS number on the label refer to it?
• Does the certificate report an intact mass, and at what resolution?
• Is the oxidised methionine variant reported separately?
• Does the lot on the certificate match the vial?

Sermorelin vs tesamorelin vs ipamorelin

These three names often appear together in Canadian vendor listings, and "sermorelin vs tesamorelin" and "tesamorelin vs ipamorelin" are common searches. On paper they are three different molecules:

A mass result is enough to tell any two of them apart. A label naming one and a certificate reporting the mass of another is a mismatch whatever the purity figure. Detailed notes: tesamorelin, ipamorelin, CJC-1295 DAC and no-DAC.

Sermorelin in Canada: catalogue status

Hermetica does not stock sermorelin, so there is no sermorelin price, SKU or certificate on this site. If a line is added it will have its own product page and lot certificate, linked here and from the catalogue.

Not covered here

There is no information on this page about amounts, routes, effects or outcomes in people or animals, and no regulatory statement is made.

Related pages

• Janoshik peptide COA checklist
• How to vet a research peptide supplier in Canada
• Ipamorelin Canada — pentapeptide identity notes
• Buy peptides Canada — the live RUO catalogue
• Research peptide shop

Sermorelin Canada: FAQ

What is sermorelin?

The synthetic amide of the first 29 residues of growth hormone-releasing hormone, GHRH(1-29)-NH2. CAS 86168-78-7, formula C149H246N44O42S, 3357.9 g/mol (PubChem CID 16132413).

Does Hermetica sell sermorelin in Canada?

No. Hermetica does not stock sermorelin. There is no sermorelin SKU, price, lot or certificate on this site.

What is a sermorelin peptide?

The same compound. "Sermorelin peptide" is a supplier listing phrase for the 29-residue GHRH(1-29) amide; it should still carry CAS 86168-78-7, a fill mass and a lot-matched certificate.

What is the difference between sermorelin and tesamorelin?

Length and one modification. Sermorelin is 29 unmodified residues (~3,358 Da); tesamorelin is the full 44-residue GHRH chain with a trans-3-hexenoyl group on Tyr1 (~5,136 Da).

What is the difference between sermorelin and ipamorelin?

They are unrelated structures. Sermorelin is a 29-residue GHRH fragment (~3,358 Da); ipamorelin is a synthetic 5-residue peptide (~712 Da), CAS 170851-70-4.

Does Hermetica give dosing or usage information for sermorelin?

No. Hermetica gives no human-use, dosing or therapeutic information for any compound, and sermorelin is not stocked.

References

1. PubChem. Sermorelin, CID 16132413: molecular formula C149H246N44O42S, molecular weight 3357.9 g/mol; synonym CAS 86168-78-7; sequence Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2. pubchem.ncbi.nlm.nih.gov/compound/16132413
2. Prakash A, Goa KL. (1999). Sermorelin. BioDrugs, 12(2), 139–157. doi:10.2165/00063030-199912020-00007
3. D'Hondt M, Bracke N, Taevernier L, Gevaert B, Verbeke F, Wynendaele E, De Spiegeleer B. (2014). Related impurities in peptide medicines. Journal of Pharmaceutical and Biomedical Analysis, 101, 2–30. doi:10.1016/j.jpba.2014.06.012

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