Tesamorelin Peptide Canada — Identity Notes (Not Stocked, RUO)

Hermetica Research Labs does not currently stock tesamorelin. There is no tesamorelin product page, lot or certificate of analysis on this site, and nothing on this page is an offer to sell tesamorelin. The notes below are for laboratories documenting tesamorelin reference material from another source. They cover structure, labelling and certificate review only and say nothing about use in humans or animals.

Key takeaways

Tesamorelin in one table

Salt forms, such as an acetate, carry their own CAS entries and a different formula weight. Record the CAS printed on the label and confirm the certificate refers to the same form.

Sequence and the one change that defines it

The peptide chain is the full 44-residue GHRH sequence:

Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2

What turns this sequence into tesamorelin is the trans-3-hexenoyl group on the amino group of Tyr1. Without it, the molecule is unmodified GHRH(1–44) amide, about 96 Da lighter. That difference is the single most useful identity check: a mass result near 5040 Da instead of 5136 Da points to the unmodified peptide, not tesamorelin.

Points to check on a tesamorelin certificate

• Intact mass. Expect multiply charged ions in an electrospray spectrum. The deconvoluted mass should be consistent with ~5135.9 Da.
• The N-terminal group. A report that confirms the hexenoyl modification, for example through fragment data, is stronger evidence than mass alone.
• Methionine 27. Peptides containing methionine can show an oxidised variant 16 Da heavier. A certificate that reports it separately tells you more than a single purity figure.
• Purity method. Note the HPLC method and detection wavelength next to the percentage; the number cannot be compared across reports without them.
• Lot match. The lot on the certificate must be the lot printed on the vial.

How tesamorelin differs from sermorelin and CJC-1295 on paper

All three are catalogued as GHRH-derived peptides, and suppliers sometimes list them side by side, so receiving errors are easy. Tesamorelin has all 44 residues plus the N-terminal hexenoyl group. Sermorelin is only the first 29 residues with no N-terminal modification, at about 3357.9 Da. CJC-1295 is a 29-residue analogue with four substituted positions and, in one form, an added lysine-linked group. A label that names one of these and a certificate that reports the mass of another is a mismatch, whatever the purity figure says. See Sermorelin identity notes and CJC-1295 and Ipamorelin identity notes.

A short receiving record for tesamorelin

1. Compound name and fill mass as printed on the vial.
2. CAS number and salt form, if stated.
3. Supplier lot number, matched to the certificate.
4. Certificate issuer, test or accession number, and the date you verified it on the issuer's own system.
5. Reported intact mass and purity with method.
6. Storage condition as stated by the supplier.

Listing errors that a careful record catches

Four mistakes come up when GHRH-derived peptides are listed or labelled, and each leaves a trace in the paperwork:

1. Unmodified chain sold under the tesamorelin name. The mass comes in about 96 Da low, near 5040 Da.
2. Sermorelin shipped instead. The mass is roughly 1,780 Da lower, near 3358 Da, because the chain stops at residue 29.
3. A salt-form CAS on the label and a free-base mass on the certificate. This is not necessarily an error, but the record should say which form each document describes.
4. A certificate for a different lot. It documents that lot only; the vial in hand remains undocumented.

Questions to put to a supplier

• Which form is supplied, free base or a named salt, and which CAS number applies to it?
• Does the certificate confirm the N-terminal hexenoyl group, or only the intact mass?
• Is the lot on the certificate the lot printed on the vial?
• Can the test or accession number be checked on the issuing laboratory's own system?

What is tesamorelin?

Tesamorelin is a synthetic 44-residue peptide amide. Chemically it is the full growth hormone–releasing hormone sequence, GHRH(1–44)-NH2, with one addition: a trans-3-hexenoyl group attached to the N-terminal tyrosine. That single acyl group is what separates tesamorelin from unmodified GHRH(1–44) on a certificate, and it accounts for the ~96 Da mass difference described above. In a laboratory file, "what is tesamorelin" is answered by three fields: the 44-residue sequence, the N-terminal hexenoyl modification and the C-terminal amide.

Tesamorelin peptide Canada: product-intent searches

Searches for "tesamorelin peptide Canada" and "buy tesamorelin Canada" usually land on vendor product pages. Hermetica does not stock tesamorelin, so there is no SKU, price or lot certificate here. This page remains an identity and documentation note only. If a line is added, it will appear on the catalogue with its own product page and certificate, linked from here.

Until then, use the identity table and certificate checklist above when documenting tesamorelin reference material sourced elsewhere. Related: CJC-1295 DAC vs no-DAC, sermorelin Canada, ipamorelin Canada.

Tesamorelin in Canada: catalogue status

Searches for tesamorelin in Canada often land on vendor pages that list the compound without a lot-matched certificate. Hermetica does not stock tesamorelin, so there is no tesamorelin price, SKU or certificate here. If that changes, a product page with its own lot certificate will be linked from this page and from the catalogue. Until then, Canadian laboratories documenting tesamorelin from another source can use the identity table, certificate points and receiving record on this page, together with the peptide COA checklist for Canada and the supplier vetting guide.

Scope of this page

No amounts, administration routes, effects or outcomes are discussed, and no regulatory statement is made. Material described here is a laboratory reagent for in-vitro work only.

Related pages

• Sermorelin Canada — 29-residue identity notes
• How to read a RUO Certificate of Analysis
• What does 99% purity mean on a peptide COA?
• Buy peptides Canada — what Hermetica does stock
• Certificates of Analysis

Research Use Only. Not for human or veterinary use. Purchasers must be 21 or older.

Frequently asked questions

Does Hermetica sell tesamorelin in Canada?

No. Hermetica does not stock tesamorelin. There is no product page, price, lot or certificate for it on this site.

What is tesamorelin chemically?

A 44-residue GHRH analogue with an N-terminal trans-3-hexenoyl group. PubChem lists it as C221H366N72O67S with a molecular weight of 5136 g/mol.

What should a tesamorelin certificate show?

An intact-mass identity result that fits the expected molecular weight, an HPLC purity figure, the lot number and the issuing laboratory with a report number.

How is tesamorelin different from sermorelin?

Sermorelin is GHRH(1–29) amide, 29 residues. Tesamorelin is the full 44-residue sequence with an added hexenoyl group, so the two have very different masses.

References

1. PubChem. Tesamorelin, CID 16137828: molecular formula C221H366N72O67S, molecular weight 5136 g/mol. pubchem.ncbi.nlm.nih.gov/compound/16137828
2. D'Hondt M, Bracke N, Taevernier L, Gevaert B, Verbeke F, Wynendaele E, De Spiegeleer B. (2014). Related impurities in peptide medicines. Journal of Pharmaceutical and Biomedical Analysis, 101, 2–30. doi:10.1016/j.jpba.2014.06.012
3. International Council for Harmonisation. (2023). ICH Q2(R2) Guideline on validation of analytical procedures, Step 5 (EMA/CHMP/ICH/82072/2006). ema.europa.eu (PDF)

Research Use Only. Not for human or veterinary use. Purchasers must be 21 or older.