AOD-9604 Canada — 16-Residue RUO Identity Notes (Not Stocked)
AOD-9604 as a laboratory identity record: sequence, the internal disulfide bond, CAS, formula, mass and the label confusion around growth hormone fragment names. Not stocked. RUO, 21+.
Hermetica Research Labs does not currently stock AOD-9604. There is no AOD-9604 product page, lot or certificate of analysis on this site, and nothing on this page is an offer to sell it. Canadian laboratories searching "AOD 9604 Canada" often need a way to document material from another supplier, so this page sets out the identity fields, the mass check that confirms the disulfide ring, and what a certificate should show. It deals with structure, labels and certificates only.
Key takeaways
| Question | Short answer | Source |
|---|---|---|
| Does Hermetica sell AOD-9604? | No: no SKU, lot or certificate | Hermetica catalogue |
| Sequence | 16 residues, YLRIVQCRSVEGSCGF, Cys7–Cys14 disulfide | DrugBank DB06388 |
| CAS / formula | 221231-10-3 / C78H123N23O23S2 | DrugBank DB06388 |
| Average weight | 1815.1 g/mol (bonded form) | DrugBank DB06388 |
| Origin | Synthetic C-terminal fragment of human GH with an added N-terminal tyrosine | Cox et al. 2015; Heffernan et al. 2001 |
| Lab detection | LC-MS/MS method validated to 50 pg/mL; 6 metabolites seen in vitro | Cox et al. 2015 |
What is AOD-9604 peptide?
AOD-9604 is a synthetic 16-amino-acid peptide. Cox et al. (2015) describe it as the C-terminal fragment of human growth hormone from amino acids 177–191 with an additional tyrosine at the N-terminus. Heffernan et al. (2001) describe it as a fragment synthesised from the C-terminus of human GH. DrugBank (DB06388) records the full sequence as a cyclic (7→14) disulfide, which is the reference structure used below.
Identity fields
| Field | Reference value |
|---|---|
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe |
| One-letter code | YLRIVQCRSVEGSCGF |
| Disulfide | Cys7–Cys14 |
| C-terminus | Free acid (Phe-OH) |
| CAS number | 221231-10-3 |
| Molecular formula | C78H123N23O23S2 |
| Average molecular weight | 1815.1 g/mol |
| Hermetica catalogue status | Not stocked |
The disulfide bond is the key identity check
- Oxidised (disulfide-bonded) form: about 1815.1 Da, the reference value.
- Reduced form (two free thiols): about 1817.1 Da, 2 Da heavier.
- Disulfide-linked dimers: roughly double, about 3630 Da.
A certificate reporting an intact mass near 1815 Da supports the bonded form. Nominal-mass instruments may not resolve 2 Da cleanly, so record the resolution the laboratory used.
What published analytical work shows
Cox et al. (2015) validated a solid-phase extraction method with a limit of detection of 50 pg/mL in urine, identified six potential metabolites after in-vitro incubation in serum and urine, and found one fragment, CRSVEGSCG, to be markedly more stable than the parent peptide. For a receiving laboratory, the useful point is analytical: the Cys-containing core is the most stable part of the molecule, and LC-MS/MS can identify the intact peptide and its fragments at very low levels.
Name confusion on labels
Products are also sold under growth hormone fragment names such as "Fragment 176-191". Do not rely on the name. Record the full sequence printed by the supplier, the CAS number and the reported mass, and check them against the table above.
Reading an AOD-9604 certificate
- Identity by mass. Observed mass against the expected 1815.1 Da.
- Purity by HPLC. Method and wavelength; reduced and dimer forms may show as separate peaks.
- Free acid C-terminus. An amidated version would differ by about 1 Da.
- Lot and issuer. The lot must match the vial; the test number should be verifiable on the lab's own system.
See how to read a peptide COA for the general method.
Documentation parallels in the Hermetica catalogue
No peptide Hermetica stocks has this structure, but the MOTS-c 10mg listing shows a complete record for another 16-residue peptide, and the BPC-157 10mg listing does the same with a Janoshik Analytical test number. Both live research pages, Buy MOTS-c Canada and Buy BPC-157 Canada, show the identity table format.
FAQ
Can I buy AOD-9604 in Canada from Hermetica?
No. Hermetica does not stock AOD-9604. There is no AOD-9604 product, lot or certificate on hermeticalabs.store, and this page is a documentation reference only.
What is the AOD-9604 sequence?
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe, 16 residues, with a Cys7–Cys14 disulfide. DrugBank (DB06388) lists the same sequence as a cyclic (7→14) disulfide.
What CAS number and molecular weight are listed for AOD-9604?
CAS 221231-10-3, formula C78H123N23O23S2, average weight 1815.1 g/mol, per DrugBank DB06388.
How do I check an AOD-9604 certificate?
Match the reported intact mass to about 1815.1 Da (disulfide-bonded form). A value near 1817.1 Da points to the reduced, ring-open form. Also check the full sequence, CAS, HPLC method and lot.
Does Hermetica give usage or dosing guidance for AOD-9604?
No. Hermetica does not sell AOD-9604 and gives no human-use, dosing or therapeutic information. Laboratory reagents are for in-vitro research only.
Scope
This page gives no information on amounts, administration, effects or outcomes in people or animals and makes no regulatory statement.
References
- DrugBank. AOD9604 (DB06388): formula C78H123N23O23S2, average weight 1815.1 g/mol, CAS 221231-10-3, cyclic (7→14) disulfide. go.drugbank.com/drugs/DB06388
- Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D. (2015). Detection and in vitro metabolism of AOD9604. Drug Testing and Analysis, 7(1), 31–38. doi:10.1002/dta.1715
- Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. (2001). The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology, 142(12), 5182–5189. doi:10.1210/endo.142.12.8522
Related pages
- KLOW peptide Canada — blend documentation
- What does 99% purity mean on a peptide COA?
- Buy peptides Canada — the live RUO catalogue
- Certificates of Analysis
Research Use Only. Not for human or veterinary use. Purchasers must be 21 or older.
All content is provided for informational purposes for qualified researchers working with research materials in a laboratory setting. Products supplied by Hermetica Research Labs are sold strictly for in-vitro research. They are not intended for human or veterinary use, and nothing on this page constitutes medical, health, or dosing guidance. Must be 21+ to purchase.
Order RUO research materials
Flat $15 shipping across Canada · Free on orders of $150 or more · Canada only · 21+ · Research Use Only, not for human or veterinary use.
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